姓名： 彭海生 博士 硕士生导师
职称职务：教授 教师教学发展中心主任、基础医学部专任教师
荣誉：曾获大庆市新长征火炬突击手、大庆市青年科技奖、大庆市优秀科技工作者、哈医大优秀教师、哈医大优秀党员等荣誉称号。
社会兼职：现为世界医药联合会理事/中药药剂专业委员会理事、医药高等教育创新实验教材建设委员会副主任委员、黑龙江省生物医学工程协会理事、大庆市入选高端人库专家；Pharmacologia及中国医药导报等杂志编委; 为ACS nano等20余个SCI杂志审稿专家。为国际控释协会会员、NSFC一审专家、教育部硕士论文函审专家、省重大项目评审专家、中华医学会奖评审专家、大庆市十三五（科技/生物类）规划评审专家及哈商大硕士研究生导师。
研究方向：生物材料合成与纳米靶向制剂机理研究
主讲课程：《药理学》、《药剂学》、《分子药剂学》
发表代表性论文：
1.Wenyuan Zhang†, Man Zhao†, Yali Gao†, Xu Cheng, Xiaoying Liu, Shukun Tang, Yanbo Peng, Na Wang, Dandan Hu, Haisheng Peng*, Jinqiu Zhang*, and Qun Wang* Dandan Hu, Jinqiu Zhang*, Haisheng Peng*, and Qun Wang*. Biomimetic erythrocytes engineered drug delivery for cancer therapy. Chemical engineering journal. 2022, 433: 133498.
2.Wenhua Li, Zhong Chen, Xiaoying Liu, Mingming Lian, Haisheng Peng*, and Changmei Zhang*. Design and evaluation of Glutathione responsive glycosylated comptothecin nanosupramolecular prodrug. Drug Delivery. 2021;28(1):1903-1914
3.Shukun Tang†, Zahra Davoud†, Guangtian Wang†, Zihao Xu, Tanzeel Rehman, Aleksander Prominski, Bozhi Tian, Kaitlin M. Bratlie, Haisheng Peng*, and Qun Wang*. Soft Materials as Biological and Artificial Membranes. Chemical society review. 2021, 2021, 50(22): 12679-12701.
4.Wenhua Li, Xiaoying Liu, Xu Cheng, Wenyuan Zhang, Chen Gong, Chuya Gao, Haisheng Peng, Bo Yang*, Shukun Tang*, Haiquan Tao*. Effect of Malt-PEG-Abz@RSL3 micelles on HepG2 cells based on NADPH depletion and GPX4 inhibition in ferroptosis. Journal of Drug Target. 2021, 11; 1-11.
5.Liwang Shi1, Jinqiu Zhang1, Man Zhao1, Shukun Tang, Xu Cheng, Wenyuan Zhang, Wenhua Li, Xiaoying Liu, Haisheng Peng*, Qun Wang* Effects of polyethylene glycol on the surface of nanoparticles for targeted drug delivery. Nanoscale. 2021; 13(24): 10748-10764
6. Ren YC, Yuan BC, Hou SH, Sui YL, Yang TH, Lv ML, Zhou YL, Yu H, Li S, Peng HS*, Chang ND*, Liu Y*. Delivery of RGD-modified liposome for targeted colorectal carcinoma therapy and study of its autophagy mechanism. Journal of Drug Target. 2021; 29(8):863-874.
7.Liao JH1, Peng HS1, Liu C, Li D, Yin YH, Lu B, Zheng H*, Wang Q*. Dual pH-responsive-charge-reversal micelle platform for enhanced anticancer therapy. Materials Science and Engineering: C. 2021, 111527.
8.Li MH‡, Tang XF‡, Liu XY, Cui XY, Lian MM, Zhao M, Peng HS*, Han XJ*. Targeted miR-21 loaded liposomes for acute myocardial infarction. Journal of Materials Chemistry B 2020. 8.10384-10391
9.Chen Z, Peng HS*, Zhang CM*. Advances in kidney-targeted drug delivery systems. International Journal of Pharmaceutics. 2020, 587: 119679
10.Chen Z, Li WH, Shi LW, Jiang L, Li MH, Zhang CM*, and Peng HS*. Kidney Targeted Astaxanthin Natural Antioxidant Nanosystem for Diabetic Nephropathy Therapy. European Journal of Pharmaceutics and Biopharmaceutics. 2020, 156: 143-154
11.Wang N1, Zhang WY1, Hu DD1, Jiang L, Liu XY, Tang SK, Zhou XG, Liu T, Tang XF, Chai YQ, Li MH, Peng HS*, and Du ZM*. ‘Prodrug-like’ acetylmannosamine modified liposomes loaded with arsenic trioxide for the treatment of orthotopic glioma in mice. Journal of Pharmaceutical Sciences. 2020, 109(9): 2861-2873.
12.Zhang CM, Chen Z, Li WH, Liu XY, Tang SK, Jiang L, Li MH, Peng HS*, and Lian MM*. Influences of Different Sugar Ligands on Targeted Delivery of Liposomes. Journal of Drug Targeting. 2020, 28(35): 1-28.
13.Yang B1, Jiang JQ1, Jiang L1, Zheng PY, Wang FL, Zhou Y, Chen Z, Li MH, Lian MM, Tang SK, Liu XY*, Peng HS*, and Wang Q*. Chitosan mediated solid lipid nanoparticles for enhanced liver delivery of zedoary turmeric oil in vivo. International Journal of Biological Macromolecules. 2020, 149(15): 108-115.
14.Jiang L1, Wang JH1, Jiang JQ1, Zhang CM, Zhao M, Chen Z, Wang N, Hu DD, Liu XY, Peng HS*, Lian MM*. Sonodynamic Therapy in Atherosclerosis by Curcumin Nanosuspensions: Preparation design, Efficacy Evaluation, and Mechanisms Analysis. European Journal of Pharmaceutics and Biopharmaceutics. 2020,146: 101-110.
15.Liao JH, Peng HS, Wei X, Song YJ, Liu C, Li D, Yin YH, Xiong X, Zheng H*, Wang Q*. A bio-responsive 6-mercaptopurine/doxorubicin based “Click Chemistry” polymeric prodrug for cancer therapy. Materials Science and Engineering: C. 2020,108: 10461
16.Liu XY1, Tang SK1, Liu YC1, Hu DD, Zhang CM, Zhang WY, Chai YQ, Tang XF, Jiang L, Gong C, Peng HS*, Li MH*. Targeting Regulation of Dually Modified Liposomes by Polyethylene Glycol Length of Vesicle Surface. Journal of Biomedical Nanotechnology. 2019; 12(15): 2413-2427
17.Zhang DP, Lian MM*, Liu J, Tang SK, Liu GZ, Ma CF, Meng QW, Peng HS*, Zhu DL. Preparation of O-Protected Cyanohydrins by Aerobic Oxidation of α-Substituted Malononitriles in the Presence of Diarylphosphine Oxides. Organic Letters. 2019, 8(21): 2597-2601
18. Poovaiah N1, Davoudi Z1, Peng HS1, Schlichtmann B, Mallapragada SK, Narasimhan B. and Wang Q.* Treatment of Neurodegenerative Disorders through the Blood-brain Barrier using Nanocarriers. Nanoscale. 2018, 10, 16962-16983
19. Liu DM, Tang SK, Wang GT, Li MH, Liu XY, Tao HQ, Ren YC, Jiang CL*, Peng HS*, and Lian MM*. The Influences of Dynamic Transport of GLUT1 on the Distribution of Mannosylated Liposomes in Transient Ischemia Reperfusion Mice Brain. J. Biomed Nanotech. 2017; 13(17): 638-654.
主持或参与课题：
1.企业委托项目，乳核內消颗粒工艺复核研究，2021.9-2021.11，在研，支持，1.2万元
2. 医院委托项目， 大庆市中医院院内制剂备案研究，2019.8-2021.9，在研，主持 168万
3. 企业委托项目，抗感泡腾片的放大工艺研究，2018/9-2019/3，准备结题，主持45万
4. 国家自然基金面上项目，糖/抗体/肽靶向纳米载体的表面(层)物质基础对缺血心肌miR-1/MMP9/Glut1摄取调控机制，81671814，2017/1-2018/12，结题，主持 25万
5. 黑龙江自然基金重点项目，微环境响应性心靶向纳米复合体的构建与疗效研究，ZD2016013，2016/7-2019/7，结题，主持 20万
6. 哈尔滨医科大学于维汉院士杰出青年培养基金，心肌靶向制剂的设计与相关机理研究，2015/1-2017/12，结题，主持 30万
7. 哈尔滨医科大学（大庆）优秀硕导基金，心肌靶向制剂研究，DSJJ2015004，2015/1-2017/12，结题，主持 （Postgraduate Tutor Foundation of Harbin Medical University-Daqing） 3万
8. 哈尔滨医科大学研究生创新基金，YJSCX2015-60HYD，光敏脂质体对心肌缺血的疗效研究，2015/7-2017/7，结题，指导 0.5万
9. 黑龙江省教育厅项目，12541348，新型脑区靶向性脂质体的分布调控及机制研究，2014/1- 2016/12，结题，主持 2.5万
10. 国家自然青年科学基金项目，81402865，抗体修饰的miR-21脂质体靶向急性缺血心肌的研究，2015/1-2017/12，在研，指导 23万
编写教材：
1.《中药药剂学》科学出版社 十四五规划教材 编委
2..《药剂学》中国医药科技出版社 十四五规划教材 编委
3.《药剂学实验》（双语）中国医药科技出版社 副主编
4.《药剂学实验》 中国医药科技出版社 主编
5. 《药物制剂技术》 科学出版社 参编
专利：
一种载有正电聚合物/miR-195复合物的脑靶向纳米脂质体及其制备方法与应用 （202010121226.2）
2. 糖-聚乙二醇-DSPE偶联化合物及其制备方法和应用（201811062535.68）
3. 热激活延迟荧光（TADF）纳米探针及其制备方法和在生物成像中的应用（201811325113.3）
4. 一种乙酰化糖酯-聚乙二醇磷脂酰乙醇胺共轭物及其制备方法与应用 （201810301839.7）
5. 一种心脑双靶向脂质体及其制备方法和应用 （201810299429.3）
6. 一种抗心肌肌钙蛋白抗体修饰并载有miR-21的脂质体及其制备方法和应用（20181098620.X）
7. 一种基于PPV病毒样颗粒的纳米递药系统及其制备方法和应用 （201510593848.4）
