师资队伍
副高职称

俞樟森

2022年01月01日 21:09  点击:[]

 

 


姓名:俞樟森 博士 硕士生导师

职称职务:高级实验师,医学实验中心主任

研究方向:纳米医学

主讲课程:《医学物理学》《临床检验仪器学》《医学影像设备学》

教育经历:

2001.09 - 2005.06 304永利集团官网入口,物理学专业,获理学学士学位

2005.09 - 2007.06 武汉大学,生物物理学专业,获理学硕士学位

2014.09 - 2018.06 中国科学院宁波材料技术与工程研究所,材料物理与化学专业,获工学博士学位

主要从事新型纳米药物的研发、毒理学评估及其在恶性肿瘤、氧化应激类疾病的诊断与治疗领域的应用研究。目前,主持及参与省部级及以上项目5,Advanced Healthcare Materials、Journal of Nanobiotechnology、Nanoscale等期刊发表SCI论文30余篇,其中第一/通讯作者SCI论文17篇;申请发明专利7项,授权2项。

研究领域:

1. 纳米药物在肿瘤靶向成像与治疗中的应用研究

2. 近红外荧光纳米探针在体外检测及肿瘤成像领域的应用

3. 纳米酶在氧化应激类疾病治疗中的应用研究

联系方式:E-mail: yzs@usx.edu.cn

代表性论文

  1. Siqi Geng, Qiang Feng, Chujie Wang, Ying Li, Jiaying Qin, Mingsheng Hou, Jiedong Zhou, Xiaoyu Pan, Fei Xu, Baoru Fang, Ke Wang, Zhangsen Yu (*), A Versatile PDA(DOX) Nanoplatform for Chemo-Photothermal Synergistic Therapy Against Breast Cancer and Attenuated Doxorubicin Induced Cardiotoxicity, Journal of Nanobiotechnology, 2023, 21: 338.

  2. Qiang Feng, Hongting Xu, Xiaoyu Pan, Siqi Geng, Huifeng Qian, Chujie Wang, Ying Li, Jiaying Qin, Yiting Wu, Bangyi Zhou, Xiaoyu Liu, Zhiqiu Ye*, Yingchun Xu*, Zhangsen Yu (*), Antioxidation and Anti-Inflammatory Acitivity of Prussian Blue Nanozymes to Alleviate Acetaminophen Induced Acute Liver Injury, ACS Applied Nano Materials, 2023, 6(10): 8468-8481.

  3. Bangyi Zhou, Chenhui Yin, Qiang Feng, Yiting Wu, Xiaoyu Pan, Chuang Liu, Jinjin Tian, Siqi Geng, Kexin Wang, Jie Xing, Yi Cao, Pingbo Shou, Zhangsen Yu(*), Aiguo Wu(*), Polypyrrole Based Nanotheranostic Agent for MRI Guided Photothermal-Chemodynamic Synergistic Cancer Therapy, Nanoscale, 2021, 13(45): 19085-19097.

  4. Qinqing Qian, Yun Zhang, Yuan Chen, Chenqiao Ye, Qiang Feng, Jinqing Tu, Zhenbo Lu, Yilan Xu, Na Ran, Guiying Xing, Zhangsen Yu (*), Assessment of Pulmonary Toxicity of Potential Antioxidant Drug PEGylated Nanoceria after Intratracheal Instillation in Rats, Journal of Applied Toxicology, 2021, 41(6): 941-952.

  5. Pingbo Shou, Zhangsen Yu (*), Yiting Wu, Qiang Feng, Bangyi Zhou, Jie Xing, Chuang Liu, Jinqing Tu, Zhiqiu Ye, Xiaojuan Zhang, Zhenbo Lu, Luyun Zhang, Aiguo Wu(*), Zn(2+) Doped Ultra-Small Prussian blue Nanotheranostic Agent for Breast Cancer Photothermal Therapy under MR Imaging Guidance, Advanced Healthcare Materials, 2020, 9(1), 1900948.

  6. Yuan Chen, Xiaoxiao Fei, Chenqiao Ye, Qinqing Qian, Zhiqiu Ye, Siqi Xie, Jiamin Chen, Mingliao Zhu, Na Ran, Mingsheng Hou, Lin Xu, Zhangsen Yu (*), Acute hepatotoxicity of multimodal targeted imaging contrast agent NaLuF4:Gd,Yb,Er-PEG/PEI-FA in mice, Journal of Toxicological Sciences, 2019, 44(9):621-632.

  7. Zhangsen Yu, Yuanzhi Xia, Jie Xing, Zihou Li, Jianjun Zhen, Yinhua Jin, Yuchen Tian, Chuang Liu, Zhenqi Jiang, Juan Li*, Aiguo Wu*, Y1 receptor ligand functionalized ultrasmall upconversion nanoparticles for tumor targeted trimodality imaging and photodynamic therapy with low toxicity. Nanoscale, 2018, 10, 17038-17052. (Featured in Outside Back Cover)

  8. Chuang Liu, Shan Sun, Qiang Feng, Gongwei Wu, Yiting Wu, Na Kong, Zhangsen Yu, Junlie Yao, Xingcai Zhang, Wei Chen, Zhongmin Tang, Yufen Xiao, Xiangang Huang, Aman Lv, Chenyang Yao, Haibo Cheng, Aiguo Wu, Tian Xie, Wei Tao, Arsenene Nanodots with Selective Killing Effects and their Low-Dose Combination with ß-Elemene for Cancer Therapy, Advanced Materials, 2021, 33(37): 2102054.

  9. Jie Xing, Qiuyu Gong, Ruifen Zou, Zihou Li, Yuanzhi Xia, Zhangsen Yu, Yufan Ye, Lingchao Xiang, Aiguo Wu, A novel fibroblast activation protein targeted near infrared fluorescent off-on probe for cancer cell detection, in vitro and in vivo imaging, Journal of Materials Chemistry B, 2018, 6, 1449-1451.

  10. Yuanzhi Xia, Xuehua Ma, Junhua Gao, Guoxin Chen, Zihou Li, Xiaoxia Wu, Zhangsen Yu, Jie Xing, Li Sun, Huimin Ruan, Lijia Luo, Lingchao Xiang, Chen Dong, Wenzhi Ren, Zheyu Shen*, Aiguo Wu*, A flexible caterpillar like gold nanoparticle assemblies with ultrasmall nanogaps for enhanced dual modal imaging and photothermal therapy. Small, 2018, 14(19): 1800094.

 

申请/授权专利:

1. 吴爱国,俞樟森,杨方,李娟,《一种多波长激发、上/下转换荧光共存的多壳层结构的纳米发光材料及其制备方法》,申请号:201711173236.5。

2. 吴爱国,俞樟森,杨方,《一种上转换荧光成像系统及上转换荧光的成像方法》,申请号:201711174200.9。

3. 吴爱国,俞樟森,杨方,一种上转换荧光数字全息成像系统及数字全息成像方法,授权,专利号:ZL 2017 1 1173737.3。

4. 吴爱国,俞樟森,一种近红外荧光发射的纳米材料及其制备方法,申请号:201711173273.6。

5. 俞樟森,钱沁清,张建华,孙爱静,张衡,方剑,张小娟,一种食源性致病菌现场快速检测方法,授权,专利号:ZL 2018 1 0397550.X。

6. 俞樟森,寿平波,叶知秋,陆振波,丰强,吴逸婷,一种Zn2+掺杂超小粒径普鲁士蓝纳米探针的制备方法,申请号:201811247647.9。

7. 寿平波,俞樟森,屠金卿,叶知秋,丰强,周邦翼,吴逸婷,一种用于光辅助治疗实验的仪器,申请号:201910179117.3。

 

主持/参与项目:

  1. 新型多功能纳米声敏剂的构建及声动力/免疫协同靶向治疗肝癌的疗效研究,LGF21H180005,浙江省自然基金委,主持,2021.01 - 2023.12,在研。

  2. 透明质酸-普鲁士蓝纳米酶对骨关节炎早期诊断及靶向治疗的作用以及机制研究,浙江省自然基金委,项目骨干2/72022.01 – 2024.12,在研。

  3. 时序释放E7短肽/miR-217激动剂的无细胞水凝胶在骨缺损修复中的应用研究,浙江省自然基金委,参与(4/7),2022.01 – 2024.12,在研。

  4. 基于NaCeF4壳层结构上转换荧光纳米探针的H2O2超灵敏检测方法研究,2018C10011,绍兴市科技计划项目,主持,2019.01 - 2020.12,结题。

  5. 温敏型超声造影剂在肝癌射频消融/免疫协同治疗中的应用基础研究,2022A14026绍兴市科技计划项目,项目骨干2/72023.01 - 2025.12在研

  6. 普鲁士蓝改善阿霉素诱导心肌损伤的作用及机制研究,LTGY23H020002浙江省自然基金委,项目骨干2/72023.01 - 2025.12在研

  7. 线粒体功能级联调控对肝缺血再灌注损伤的保护作用及机制研究,LTGY24H030003,浙江省自然科学基金委,项目骨干2024.01 - 2026.12,在研。


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