东南大学免疫学博士、教授
职务:304永利集团官网入口党委委员、医学检验系主任
研究方向:病毒感染与免疫机制研究
主讲课程:《医学免疫学》、《感染与免疫》、《病原生物学与免疫学》
联系电话:0575-88345684
电子邮箱:sxzjh1018@126.com
主持或参与的课题(包括教改、课改项目):
1.内源性逆转录病毒在原发性肝癌中的差异表达及生物学功能研究(2018C30028),2019/01-2020/12,绍兴市科技计划一般项目,主持;
2.肠道病毒71型非结构蛋白B细胞表位的筛选与鉴定研究(LY16H190005),浙江省自然科学基金面上项目,2016/01-2018/12,主持;
3.肠道病毒71型结构蛋白VP1特异性抗原的筛选及其应用研究(2011A33003),2011/07-2014/06,绍兴市科技计划一般项目,主持;
4.FER激酶在肝细胞癌转移中的双向调控及机制研究(81101612),2011/09-2015/11,国家自然科学基金青年科学基金项目,参与;
5.非受体型酪氨酸激酶FER参与肝癌细胞转移的作用及机制研究(Y2111046),2011/01-2014/12,浙江省自然科学基金面上项目,参与;
6.肝癌转移新药靶FER的作用机制研究(2011A33002),2011/09-2014/09,绍兴市科技计划一般项目,参与;
7.伤寒和副伤寒通用型糖肽结合疫苗构建及免疫保护性研究(Y2090395),2009/01-2012/12,浙江省自然科学基金面上项目,参与。
代表性论文(包括教学改革类论文):
1. Zhang J, Wang Q, Zhao D, Cao X. Induction of potent anti-tumor immunity by direct injection of Ad-LIGHT at the site of tumor inoculation. Cytotherapy. 2007;9:386-396.
2. Jiang B, Zhang J, You X, et al. Diagnosis of hand, foot, and mouth disease caused by EV71 and other enteroviruses by a one-step, single tube, duplex RT-PCR. J Med Virol. 2012;84:1803-1808.
3. Zhang J, Dong M, Jiang B, et al. Antigenic characteristics of the complete and truncated capsid protein VP1 of enterovirus 71. Virus Res. 2012;167:337-342.
4. Zhang J, Jiang B, Xu M, et al. Identification of specific antigenic epitope at N-terminal segment of enterovirus 71 (EV-71) VP1 protein and characterization of its use in recombinant form for early diagnosis of EV-71 infection. Virus Res. 2014;189:248-253.
5. Qin B, Zhang J, Xie W, et al. Development of a Specific Latex Agglutination Test to Detect Antibodies of Enterovirus 71. Arch Med Res. 2015;46:580-587.
6. Xu M, Behloul N, Wen J, et al. Role of asparagine at position 562 in dimerization and immunogenicity of the hepatitis E virus capsid protein. Infect Genet Evol. 2016;37:99-107.
7. Chen X, Qin B, Shi M, et al. Immunoreactivity Analysis of the Nonstructural Proteins of Human Enterovirus 71. Viral Immunol. 2017;30:106-110.
8. Zhang J, Huang H, Xu L, et al. Screening and Identification of Linear B Cell Epitopes Within the Nonstructural Proteins of Enterovirus 71. Viral Immunol. 2019;32:84-88.
9. Zhao J, Wang Q, Zhang J. Changes in Microbial Profiles and Antibiotic Resistance Patterns in Patients with Biliary Tract Infection Over a Six-Year Period. Surg Infect (Larchmt). 2019.